石三军
一、个人简介
明升体育明升体育、博士生导师。哈佛大学留学归国，入选四川省中医药管理局学术和技术带头人和四川省学术和技术带头人后备人选、四川省高层次人才引进计划、四川省特聘专家、四川省杰青、省级创新创业优秀指导教师等。相关成果以第一或通讯作者身份在Angew Chem Int Edit, Biomaterials, J Control Release, Acta Pharmaceutica Sinica B等顶级杂志上发表SCI论文多篇，其中入选ESI热点论文和高被引论文3篇；参编《药剂学》、《药剂学实验指导》和英文专著4项，授权专利1项；先后主持了国家科技重大专项（726万）、国家自然科学基金等项目11项，累计经费1000余万元；成果获得两项药品注册批件、并先后获得重庆市科技进步二等奖、四川省科学技术进步三等奖、重庆市科协自然科学优秀学术论文，以及Int J Biol Macromol评审“杰出贡献奖”等奖项；中国青年创青春大赛国家级银奖、指导大学生获得R35制药学国际技能锦标赛铜奖、“互联网+”、“挑战杯”创新创业竞赛等国家级奖励7项；同时担任了本学科著名SCI期刊Curr Pharm Design客座主编、Integrative Medicine Discovery副主编、Asian J Pharm Sci和Journal of Pharmaceutical Analysis青年编委、SmartMat青年编委、《现代肿瘤医学》编委，并任世中联肿瘤精准医学专委会常务理事、中华中医药学会中成药分会委员、中国抗癌协会纳米药物专委会青年委员等职务。
邮箱：shisanjuns@163.com，明升体育科技楼西耳房1楼
二、代表性成果
（一）承担项目
1. 国家科技重大专项
2. 国家自然科学基金青年项目
3. 四川省杰出青年基金
4. 天府峨眉高层次人才项目
5. 四川省中央引导地方基金
6. 四川省级教改项目
（二）发表论文
1. Yuhong Jiang, Yuke Li, Dongmei Zheng, Xin Du, Huan Yang, Chuan Wang, Mengnan Zhao, Haihua Xiao, Lingpu Zhang*, Xiaofang Li*, Sanjun Shi*. Nano-polymeric platinum activates PAR2 gene editing to suppress tumor metastasis. Biomaterials. 2025, 123090.
2. Lan Zou, Rujing Wang, Mengnan Zhao, Yuke Li, Chen Sun, Jinjin Xie, Yan Chen, Qian Jing, Dandan Mi, Sanjun Shi*. PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors. Journal of Nanobiotechnology. 2025, 23, 35.
3. Jinjin Xie, Xin Du, Yuke Li, Chengyu Wu*, Rui Li*, Mengnan Zhao*, Sanjun Shi*. Berberine shaping the tumor immune landscape via pyroptosis. Cellular Immunology. 2025, 408: 104908.
4. Yao Wang, Rui Qu, Wenxuan Du, Wei Li, Anqi Wang, Zhoujiang Chen, Huile Gao, Di Wu, Fang Geng, Daniel Scherman, Xianwen Wang,* Sanjun Shi,* Liang Zou,* Hanmei Li*. In Situ Bioorthogonal Repair of the Vascular Endothelium Glycocalyx to Treat Acute Lung Injury. Small. 2024, 2405092, 1-13.
5. Yuke Li, Jinjin Xie, Xin Du, Yan Chen, Chuan Wang, Tiantian Liu, Zhiwen Yi, Yue Wang, Mengnan Zhao, Xiaofang Li, Sanjun Shi*. Oridonin, a small molecule inhibitor of cancer stem cell with potent cytotoxicity and differentiation potential. European Journal of Pharmacology. 2024, 975: 176656.
6. Jiaojiao Li, Dandan Mi, Ruijing Wang, Yuke Li, Mengnan Zhao*, Sanjun Shi*. A lava-inspired proteolytic enzyme therapy on cancer with a PEG-based hydrogel enhances tumor distribution and penetration of liposomes. Journal of Nanobiotechnology. 2024, 22: 216.
7.Yu Zheng, Yuke Li, Mao Li, Rujing Wang, Yuhong Jiang, Mengnan Zhao, Jun Lu*, Rui Li, Xiaofang Li*, Sanjun Shi*. COVID-19 Cooling: Nanostrategies Targeted to Cytokine Storm for Controlling Severe and Critical Symptoms. Medicinal Research Reviews. 2024, 44: 738-811. (Cover Story)
8.Yuhong Jiang, Yuke Li, Xiujuan Fu, Yue Wu, Rujing Wang, Mengnan Zhao, Canquan Mao, Sanjun Shi*. Interplay between G protein-coupled receptors and nanotechnology. Acta Biomaterialia. 2023, 169: 1-18.
9.Dandan Mi, Jiaojiao Li, Rujing Wang, Yuke Li, Lan Zou, Chen Sun, Shenao Yan, Huan Yang, Mengnan Zhao*, Sanjun Shi*. Postsurgical wound management and prevention of triple-negative breast cancer recurrence with a pyroptosis-inducing, photopolymerizable hydrogel. Journal of Controlled Release, 2023, 356: 205-218.
10.Mengnan Zhao, Rujing Wang, Kunmeng Yang, Yuhong Jiang*, Yachen Peng, Yuke Li, Zhen Zhang, Jianxun Ding*, Sanjun Shi*. Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis. Acta Pharmaceutica Sinica B, 2023; 13: 916-941.
11.Yan Chen, Rui Zhang, Dandan Mi, Qiuju Wang, Tingwenli Huang, Xinwei Dong, Hongwei Zhang, Hongtao Xiao, Sanjun Shi*. SPK1/S1P axis confers gastrointestinal stromal tumors (GISTs) resistance of imatinib. Gastric Cancer, 2023; 26: 26-43.
12.Hanmei Li, En He, Yao Wang, Jiao Fu, Tianya Liu, Rui Gou, Sanjun Shi*, Chun Gu*. Albumin-stabilized polydopamine nanoparticles for chemo-photothermal synergistic therapy of melanoma. Journal of Drug Delivery Science and Technology. 2023, 87: 104759.
13.Ruijing Wang, Lan Zou, Zhiwen Yi, Zhen Zhang, Mengnan Zhao, Sanjun Shi*. PLGA nanoparticles loaded with curcumin produced luminescence for cell bioimaging. International Journal of Pharmaceutics. 2023, 639: 122944.
14.Yao Chen, Jiru Yang, Yi Zuo, Chaozheng Zhang, Yiru Pu, QingRen, Xiao Li, Yunqian Huang, Hui Huang, HuanYang, Ouyan You, Xila Xia, Aiping Lu, Sanjun Shi*, Yun Deng*, Jun Lu*. Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway. Pharmacological Research, 2022; 184: 106415.
15.Mengnan Zhao, Dandan Mi, Bijan Emiliano Ferdows, Yuke Li, Rujing Wang, Jiaojiao Li, Dylan Patel, Sanjun Shi*, Wei Tao*. State-of-the-art nanotechnologies for the detection, recovery, analysis and elimination of blood-based biosources in cancer liquid biopsy. Nano Today, 2022; 42: 101361.
16.Hanmei Li, Qi Tang, Yao Wang, Mao Li, Yannan Wang, Hong Zhu, Fang Geng, Di Wu, Lianxin Peng, Gang Zhao, Liang Zou, Sanjun Shi*. Injectable thermosensitive lipo-hydrogels loaded with ropivacaine for prolonging local anesthesia. International Journal of Pharmaceutics. 2022, 121291.
17.Hong Wang, Yu Zheng, Qiang Sun, Zhen Zhang, Mengnan Zhao, Cheng Peng*, Sanjun Shi*. Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies. Journal of Nanobiotechnology, 2021; 19: 322.
18.Xili Lu#, Sanjun Shi#, Hanmei Li, Ethan Gerhard, Zhihui Lu, Xinyu Tan, Wenliang Li, Kevin M.Rahn, Denghui Xie, Guodong Xu, Fang Zou, Xiaochun Bai, Jinshan Guo, JianYang. Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives. Biomaterials, 2020; 232: 119719.
19.Lili Wei, Chenyuan Wang, Xianjue Chen, Bing Yang, Kun Shi, Leah R. Benington, Lee Yong Lim, Sanjun Shi*, Jingxin Mo*. Dual-responsive, methotrexate-loaded, ascorbic acid-derived micelles inhibit NF-κB signaling to exert anti-tumor and anti-metastasis effects in an orthotopic mouse model of human choriocarcinoma. Theranostics. 2019; 9(15): 4354-4374.
20.Sanjun Shi, Na Kong, Chan Feng, Aram Shajii, Claire Bejgrowicz, Wei Tao*, Omid C. Farokhzad*. Drug Delivery Strategies for the Treatment of Metabolic Diseases. Advanced Healthcare Materials. 2019, 1801655.
21. Sanjun Shi*, Min Zhou, Xin Li, et. al. Synergistic active targeting of dually integrin αvβ3/CD44-targeted nanoparticles to B16F10 tumors located at different sitxes of mouse bodies. J Control Release, 2016; 235: 1-13.
22. Sanjun Shi, Lu Han, Tao Gong, Zhirong Zhang, Xun Sun. Systemic delivery of microRNA-34a for cancer stem cell therapy. Angew Chem Int Edit, 2013; 52(14): 3901-3905.
23. Sanjun Shi, Lu Han, Li Deng, Yanling Zhang, Hongxin Shen, Tao Gong, Zhirong Zhang, Xun Sun. Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression. J Control Release, 2014; 194(28): 228-237.
（三）获奖
1. 重庆市科协自然科学优秀学术论文奖
2. 重庆市科技进步二等奖：新型抗肿瘤药物制剂关键技术及应用
3. 四川省科技进步三等奖：新型药物制剂关键技术创新与应用
4. 2022年全国高校黄大年式教师团队主要成员
5. Acta Pharmaceutica Sinica B High Impact Paper Award
6. Acta Materia Medica优秀论文
7. 四川省中医药管理局第七批学术和技术带头人
8. 四川省学术和技术带头人后备人选
9. “互联网”“挑战杯”大学生创新创业大赛优秀指导教师