明升体育

 一、个人简介

   李小芳，博士、明升体育、博士研究生导师、博士后合作导师，明升体育优势特色学科药剂学学科带头人。入选2024年全球前2％顶尖科学家“年度影响力”榜单。

   为国家中医药考试命审题专家、国家自然科学基金委同行评议专家、国家卫健委医药卫生科技发展中心科研项目评审专家、教育部学位中心评审专家、四川省院士（专家）工作站专家、四川省科技计划项目评审专家、四川省科技成果奖励评审专家、四川省药品注册现场核查专家、四川省医疗保障专家库专家、北京市自然科学基金评审专家、河北省科技计划项目评审专家。尚任中华中医药学会中药制剂分会常务委员、世界中医药学会联合会道地药材多维评价专业委员会常务理事、成都市药学会第八届药剂专业委员会副主任委员等学术职务。

   长于中药新药、中药制剂关键技术及中药新型递药系统等领域的研究。作为负责人和主研人员承担了国家“十五”科技攻关项目、国家自然科学基金项目、科技部863项目、国家“十一五”科技支撑计划以及部省级、厅局级课题共40余项；作为主研参与并取得具有代表性的科研成果有藿香正气液的研制、太极通天液的研制，均获生产批文，已上市。“藿香正气口服液的制备方法”于1997年获中国专利发明金奖，为国内首次获此殊荣的中药产品。

   公开发表学术论文260余篇， SCI论文80余篇，其中入选ESI药理学与毒理学学科高水平论文及高被引论文20余篇。

   作为主编、副主编负责编写《中药药剂学》、《中药药剂学实验》双语教材、《药剂学》、《中药提取工艺学》、《中药制药工艺学》等国家规划教材10余部。以第一发明人申请国家发明专利12项，已授权8项；获四川省及成都市科技进步奖6项。

   已培养硕、博士研究生100余名。

   联系方式：lixiaofang918@163.com

二、近期发表论文

1. Chuipeng Liang，Xing Liu, Zihao Sun，Lin Wen，Jijiao Wu, Sanjun Shi, Xiaolian Liu, Nini Luo*, Xiaofang Li*. Lipid nanosystems for fatty liver therapy and targeted medication delivery: a comprehensive review. International Journal of Pharmaceutics. 中科院二区，IF=5.3, 2025-02-09

2. Yuhong Jiang, Yuke Li, Dongmei Zheng, Xin Du,Huan Yang, Chuan Wang,  Mengnan Zhao, Haihua Xiao, Lingpu Zhang*, Xiaofang Li*, Sanjun Shi*.  Nano-polymeric platinum activates PAR2 gene editing to suppress tumor metastasis. Biomaterials. 中科院一区，IF=12.8，2025-01-22

3. Chunyan Cai, Kai Liu, Dejun Yang, Jijiao Wu, Zhaolei Peng, Yulin Wang, Jingjing Xi, Fan Xie*, Xiaofang Li*. The nanocrystal-loaded liposome of poorly water-soluble drugs (Tanshinone ⅡA ) with high drug loading and stability towards efficient liver fibrosis reversion. Nanomedicine: Nanotechnology, Biology, and Medicine. 中科院二区，IF=4.2，2024-11-27

4. Dejun Yang, Kai Liu, Chunyan Cai, Jingjing Xi, Chunmei Yan, Zhaolei Peng, Yulin Wang, Lin Jing, Ying Zhang, Fan Xie*, Xiaofang Li*. Target-Engineered Liposomes Decorated with Nanozymes Alleviate Liver Fibrosis by Remodeling the Liver Microenvironment. ACS Applied Materials & Interfaces. 中科院二区，IF:8.3，2024-11-12

5. Jijiao Wu, Lin Wen, Xiaolian Liu, Qiuxia Li, Zihao Sun, Chuipeng Liang, Fan Xie*, Xiaofang Li*. Silybin: A Review of Its Targeted and Novel Agents for Treating Liver Diseases Based on Pathogenesis. Phytotherapy Research. 中科院二区，IF:6.1，2024-09-23

6. Chunmei Yan, Yuxin Zhao, Xiaolian Liu, Yingjie Jiang, Qiuxia Li, Lu Yang, Xiaofang Li*, Kaipei Luo*. Self-Delivery Nanobooster to Enhance Immunogenic Cell Death for Cancer Chemoimmunotherapy. ACS Applied Materials & Interfaces.中科院二区，IF:9.5，2024-07-06

7. Yu Zheng, Yuxin Zhao, Zhibei Li, Min Xu, Yongping Lu, Xiaofang Li*. Puerarin-containing rhein-crosslinked tyramine-modified hyaluronic acid hydrogel for antibacterial and anti-inflammatory wound dressings. International Journal of Biological Macromolecules.中科院一区. IF:7.7，2024-05-20

8. Bolin Zhao, Kai Liu, Xing Liu, Qiuxia Li, Zhibei Li, Jingjing Xi, Fan Xie*, Xiaofang Li*. Plant-derived flavonoids are a potential source of drugs for the treatment of liver fibrosis. Phytotherapy Research. 中科院二区，IF:6.1，2024-04-13

9. Zheng Yu，Li Yuke，Li Mao, Wang Rujing，Jiang Yuhong，Zhao Mengnan， Lu Jun*，Li Rui，Li Xiaofang*，Shi Sanjun*. COVID-19 cooling: Nanostrategies targeting cytokine storm for controlling severe and critical symptoms. MEDICINAL RESEARCH REVIEWS. 中科院一区，IF:12.9，2023-11-21

10. Huan Gu，Ping Chen，Xing Liu，Yan Lian，Jingjing Xi，Jingjing Li，Jingyao Song*，Xiaofang Li*. Trimethylated chitosan-coated flexible liposomes with resveratrol for topical drug delivery to reduce blue-light-induced retinal damage. International Journal of Biological Macromolecules.中科院一区，IF:7.7，2023-10-22

11. Zhibei Li, Yu Zheng, Kai Liu, Youdan Liang, Jing Lu, Qiuxia Li, Bolin Zhao, Xing Liu, Xiaofang Li*. Lignans as multi-targeted natural products in neurodegenerative diseases and depression: Recent perspectives. Phytotherapy Research. 中科院二区，IF: 7.2，2023-09-14

12. Kaipei Luo, Lu Yang, Chunmei Yan, Yuxin Zhao, Qiuxia Li, Xing Liu, Long Xie, Qiang Sun, Xiaofang Li*. A Dual-Targeting Liposome Enhances Triple-Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation. Small. 中科院一区， IF: 13.3，2023-06-15（封面论文）

13. Qiuxia Li, Xing Liu, Chunmei Yan, Bolin Zhao, Yuxin Zhao, Lu Yang, Mingyi Shi, Hua Yu*, Xiaofang Li*, Kaipei Luo*. Polysaccharide-Based Stimulus-Responsive Nanomedicines for Combination Cancer Immunotherapy. Small. 中科院一区，IF: 13.3，2023-03-27

14. Yu Zheng, Long Xie, Dejun Yang, Kaipei Luo, Xiaofang Li*. Small-molecule natural plants for reversing liver fibrosis based on modulation of hepatic stellate cells activation: An update. Phytomedicine. 中科院一区，IF: 7.9，2023-04-12

15. Chunmei Yan, Qiuxia Li, Qiang Sun, Lu Yang, Xing Liu, Yuxin Zhao, Mingyi Shi, Xiaofang Li*, Kaipei Luo*. Promising Nanomedicines of Shikonin for Cancer. International Journal of Nanomedicine. 中科院二区，IF: 8.0，2023-03-30（ESI高被引论文）

16. Lu Jing, Xie Long，Wu Anxin，Wang Xian，Liang Youdan，Dai Xiaolin，Cao Yi，Li Xiaofang*. Delivery of silybin using a zein-pullulan nanocomplex: Fabrication, characterization, in vitro release properties and antioxidant capacity. COLLOIDS AND SURFACES B-BIOINTERFACES. 中科院二区，IF: 5.999，2022-08-23

17. Deng Mao，Chen Huijuan，Xie Long，Liu Kai，Zhang Xumin，Li Xiaofang*. Tea saponins as natural emulsifiers and cryoprotectants to prepare silymarin nanoemulsion. LWT-FOOD SCIENCE AND TECHNOLOGY. 中科院一区, IF: 6.056，2022-01-17.

18. Yi Cao，Long Xie，Kai Liu，Youdan Liang，Xiaolin Dai，Xian Wang，Jing Lu，Xumin Zhang，Xiaofang Li*. The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review. Pharmacological Research. 中科院一区，IF: 7.658，2021-11-02

19. Kai Liu，Xumin Zhang，Long Xi，eMao Deng，Huijuan Chen，Jiawen Song，Jiaying Long，Xiaofang Li*，Jia Luo*. Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy. Pharmacological Research. 中科院一区，IF: 7.658，2021-03-14（ESI高被引论文）

20. Jiaying Long，Jiawen Song，Xumin Zhang，Mao Deng，Long Xie，Linlin Zhang，Xiaofang Li*. Tea saponins as natural stabilizers for the production of hesperidin nanosuspensions. International Journal of Pharmaceutics. 中科院二区，IF=5.88, 2020-06-12