熊亮
熊亮，男，博士，博士后，研究员（二级明升体育），博士生导师，毕业于北京协和医学院&中国医学科学院药物研究所，现任明升体育药学院/现代中药产业学院副院长、西南特色药材创新药物成分研究所所长。国家“优秀青年科学基金”获得者、四川省学术技术带头人、省部级优秀人才计划入选者、四川省杰出青年基金获得者、四川省中医药管理局学术和技术带头人等。现为世界中联中药上市后再评价专业委员会常务理事、中国民族医药学会信息与大数据分会常务理事、中国研究型医院学会中西医结合新药创制专业委员会常务委员、中华中医药学会青年委员、中华中医药学会中医药防治重大疾病基础研究平台专家委员会委员、国家自然科学基金评审专家、教育部学位论文评审专家、四川省专家评议（审）委员会委员、四川省科技评审专家、Front. Chem.副主编、Chin. J. Nat. Med., World J. Tradit. Chin. Med., Chin. Med. Cult.青年编委等。
致力于活血化瘀中药治疗妇科疾病和心脑血管疾病的物质基础及作用机制研究。近年来，选择西南地区丰富的活血化瘀中药开展现代研究，如“经产良药”益母草、“上行头目、下达血海”川芎、“气中血药”姜黄与莪术、“化旧生新良药”山莨菪、“通经止痛要药”红花等。主持主研国家自然科学基金重大项目、重点项目、优秀青年基金、面上项目、青年基金、霍英东基金、国家重大新药创制专项、国家中药标准化项目、四川省杰出青年基金、中国博士后科学基金、四川省科技创新人才项目等40余项；发表论文170余篇，其中以第一作者或通讯作者发表SCI论文60余篇，出版专著7部（含十三五、十四五规划教材3部），获授权发明专利25项（含欧洲专利2项），转化9项；获四川省科技进步一等奖，中医药国际贡献奖-科技进步二等奖，华夏医学科技奖二等奖。
近5年代表性SCI论文（2018-2022）
(1) Pocahemiketone A, a sesquiterpenoid possessing a spirocyclic skeleton with a hemiketal endoperoxide unit, alleviates Aβ25?35-induced pyroptosis and oxidative stress in SH-SY5Y cells. Organic Letters, 2022, 24: 4734?4738 (通讯作者)
(2) Sesquiterpenoids from the florets of Carthamus tinctorius (Safflower) and their anti-Atherosclerotic activity. Nutrients, 2022, 14, 5348 (通讯作者)
(3) Six pairs of enantiomeric phthalide dimers from the rhizomes of Ligusticum chuanxiong and their absolute configurations and anti-inflammatory activities. Bioorganic Chemistry, 2022, 127: 105970 (通讯作者)
(4) Vasorelaxant effect of curcubisabolanin A isolated from Curcuma longa through the PI3K/Akt/eNOS signaling pathway. Journal of Ethnopharmacology, 2022, 294: 115332 (通讯作者)
(5) Curcumanes E and F, two rare sesquiterpenoids with a dicyclo[3.3.1]nonane moiety, from Curcuma longa and their vasorelaxant activities. Frontiers in Chemistry, 2022, 10: 995950 (通讯作者)
(6) Isoindolines and phthalides from the rhizomes of Ligusticum chuanxiong and their relaxant effects on the uterine smooth muscle. Phytochemistry, 2022, 198: 113159 (通讯作者)
(7) Antiproliferative and proapoptotic effects of phenanthrene derivatives isolated from Bletilla striata on A549 lung cancer cells. Molecules, 2022, 27: 3519 (通讯作者)
(8) Bioactive neolignans and lignans from the roots of Paeonia lactiflora. Chinese Journal of Natural Medicines, 2022, 20: 1-5 (通讯作者)
(9) Discovery of bletillain, an unusual benzyl polymer with significant autophagy-inducing effects in A549 lung cancer cells through the Akt/GSK-3β/β-catenin signaling pathway. Bioorganic Chemistry, 2021, 117: 105449 (通讯作者)
(10) New lignans from the fruits of Leonurus japonicus and their hepatoprotective activities. Bioorganic Chemistry, 2021, 115: 105252 (通讯作者)
(11) Recent research and development of NDM-1 inhibitors. European Journal of Medicinal Chemistry, 2021, 223: 113667 (通讯作者)
(12) Anisotanols A—D, four norsesquiterpenoids with an unprecedented sesquiterpenoid skeleton from Anisodus tanguticus. Chinese Journal of Chemistry, 2021, 39: 3375-3380 (通讯作者)
(13) Chemical composition and uterine smooth muscle relaxant activity of essential oils from 10 kinds of blood-activating and stasis-resolving Chinese medicinal herbs. Journal of Ethnopharmacology, 2021, 269: 113713 (通讯作者)
(14) Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines. Phytochemistry, 2021, 183: 112617 (通讯作者)
(15) Polyacetylene glucosides from the ?orets of Carthamus tinctorius and their anti-in?ammatory activity. Phytochemistry, 2021, 187: 112770 (通讯作者)
(16) Bisabolane-type sesquiterpenoids: Structural diversity and biological activity. Phytochemistry, 2021, 192: 112927 (通讯作者)
(17) Cardioprotective effects and concentration-response relationship of aminoalcohol-diterpenoid alkaloids from Aconitum carmichaelii. Fitoterapia, 2021, 149: 104822 (通讯作者)
(18) Seven pairs of new enantiomeric sesquiterpenoids from Curcuma phaeocaulis. Bioorganic Chemistry, 2020, 99: 103820 (通讯作者)
(19) Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells. Biomedicine & Pharmacotherapy, 2020, 131: 110724 (通讯作者)
(20) Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis. Biomedicine & Pharmacotherapy, 2020, 132: 110855 (通讯作者)
(21) Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa. Organic Letters, 2019, 21: 1197-1201 (通讯作者)
(22) Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longa. Bioorganic Chemistry, 2019, 92: 103275 (通讯作者)
(23) Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview. Biomedicine & Pharmacotherapy, 2019, 117: 109060 (通讯作者)
(24) Cytotoxicity of lanostane-type triterpenoids and ergosteroids isolated from Omphalia lapidescens on MDA-MB-231 and HGC-27 cells. Biomedicine & Pharmacotherapy, 2019, 118: 109273 (通讯作者)
(25) Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT1B receptor and c-Jun. Journal of Ethnopharmacology, 2019, 237: 39-46 (通讯作者)
(26) Discrimination of the Geographical Origin of the Lateral Roots of Aconitum carmichaelii Using the Fingerprint, Multicomponent Quantification, and Chemometric Methods. Molecules, 2019, 24: 4124 (通讯作者)
(27) New sesquiterpenoids from the stems of Dendrobium nobile and their neuroprotective activities. Fitoterapia, 2019,138: 104351 (通讯作者)
(28) Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin. Journal of Natural Products, 2018, 81: 1919-1927 (通讯作者)
(29) Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle. Phytochemistry, 2018, 145: 128-136 (通讯作者)
(30) Lanostane triterpenoids from Ganoderma luteomarginatum and their cytotoxicity against four human cancer cell lines. Phytochemistry, 2018, 156: 89-95 (通讯作者)
代表性专著教材
(1)熊亮（副主编）. 天然药物化学（全国普通高等中医药院校药学类专业“十三五”规划教材-第二轮规划教材）, 中国医药科技出版社, 2018/8, 北京.
(2)熊亮（编委）. 中药化学（全国中医药行业高等教育“十四五”规划教材-全国高等中医药院校规划教材）, 中国中医药出版社, 2021/6, 北京.
(3)熊亮（编委）. 天然药物化学实验（全国普通高等中医药院校药学类专业“十三五”规划教材-第二轮规划教材）, 中国医药科技出版社, 2018/8, 北京.
(4)熊亮（副主编）. 经产良药益母草, 四川科学技术出版社, 2017/11, 成都.
获得奖励
(1) 益母草全产业链关键技术创新与产品开发应用示范，2019年度中医药国际贡献奖-科技进步奖，二等奖
(2) 经产良药益母草的多维评价与开发应用，2017年度四川省科技进步奖，一等奖
(3) 乌头类有毒中药安全性评价模式的建立与示范，2013年度华夏医学科技奖，二等奖